Dominion

Play the ruler of a small kingdom of rivers and evergreens striving to unite small bits of land owned by petty lords who are always on the verge of anarchy. Other monarchs have the same idea and you will rival with them to claim as much land as possible. Hire minions, construct buildings, spruce up your castle, fill up your coffers... and hope that is enough to establish dominion.
 
In Dominion, each player starts with an identical, very small deck of cards. In the center of the table is a selection of other cards the players can "buy" as they can afford them. Through their selection of cards to buy, and how they play their hands as they draw them, the players construct their deck on the fly, striving for the most efficient path to the precious victory points by game end.
 
Dominion is not a CCG, but the play of the game is similar to the construction and play of a CCG deck. The game comes with 500 cards. You select 10 of the 25 Kingdom card types to include in any given play—leading to immense variety.

Note: Settlers Cafe also has Dominion: Intrigue, Dominion: Seaside (expansion), Dominion: Prosperity (expansion), and Dominion: Alchemy (expansion).